calc_ss_2cmt function

Calculate C(t) for a 2-compartment linear model at steady-state

calc_ss_2cmt(tad, tau, dose, dur = NULL, tinf = NULL, ...)

calc_ss_2cmt_linear_bolus(tad, tau, dose, ...)

calc_ss_2cmt_linear_infusion(tad, tau, dose, tinf, ...)

calc_ss_2cmt_linear_oral_0(tad, tau, dose, dur, ...)

calc_ss_2cmt_linear_oral_1_lag(tad, tau, dose, ...)

calc_ss_2cmt_linear_oral_0_lag(tad, tau, dose, dur, ...)

calc_ss_2cmt_linear_oral_1(tad, tau, dose, ...)

Arguments

• tad: Time after dose (h)
• tau: Dosing interval (h)
• dose: Dose
• dur: Duration of zero-order absorption (h)
• tinf: Duration of infusion (h)
• ...: Passed to calc_derived_2cpt()

Returns

Concentration of drug at requested time (t) at steady-state, given provided set of parameters and variables.

Functions

• calc_ss_2cmt_linear_bolus(): Calculate C(t) for a 2-compartment linear model with IV bolus dosing at steady-state
• calc_ss_2cmt_linear_infusion(): Calculate C(t) for a 2-compartment linear model with infusion at steady state
• calc_ss_2cmt_linear_oral_0(): Calculate C(t) for a 2-compartment linear model at steady-state with zero-order oral dosing
• calc_ss_2cmt_linear_oral_1_lag(): Calculate C(t) for a 2-compartment linear model at steady-state with first-order oral dosing
• calc_ss_2cmt_linear_oral_0_lag(): Calculate C(t) for a 2-compartment linear model at steady-state with zero-order oral dosing and a lag time
• calc_ss_2cmt_linear_oral_1(): Calculate C(t) for a 2-compartment linear model at steady-state with first-order oral dosing

Examples

Ct <- calc_ss_2cmt_linear_bolus(tad = 11.75, CL = 7.5, V1 = 20, V2 = 30, Q = 0.5,
    dose = 10, tau=24)
Ct <- calc_ss_2cmt_linear_infusion(tad = 11.75, CL = 7.5, V1 = 20, V2 = 30, Q = 0.5,
    dose = 10, tinf = 1, tau = 12)
Ct <- calc_ss_2cmt_linear_oral_0(tad = 23, CL = 2.5, V1 = 20, V2 = 30, Q = 0.5,
    dose = 1000, dur = 1, tau = 24)
Ct <- calc_ss_2cmt_linear_oral_1_lag(tad = 11.75, CL = 7.5, V1 = 20, V2 = 30, Q = 0.5,
    dose = 1000, ka = 1, tau=24, tlag=2)
Ct <- calc_ss_2cmt_linear_oral_0_lag(tad = 23, CL = 2.5, V1 = 20, V2 = 30, Q = 0.5,
    dose = 1000, dur = 1, tau = 24, tlag=2)
Ct <- calc_ss_2cmt_linear_oral_1(tad = 11.75, CL = 7.5, V1 = 20, V2 = 30, Q = 0.5,
    dose = 1000, ka = 1, tau=24)

References

Bertrand J & Mentre F (2008). Mathematical Expressions of the Pharmacokinetic and Pharmacodynamic Models implemented in the Monolix software. http://lixoft.com/wp-content/uploads/2016/03/PKPDlibrary.pdf

Rowland M, Tozer TN. Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications (4th). Lippincott Williams & Wilkins, Philadelphia, 2010.

Author(s)

Justin Wilkins, justin.wilkins@occams.com