calc_ss_1cmt function

Calculate C(t) for a 1-compartment linear model at steady-state

calc_ss_1cmt(tad, tau, dose, dur = NULL, tinf = NULL, ...)

calc_ss_1cmt_linear_bolus(tad, tau, dose, ...)

calc_ss_1cmt_linear_infusion(tad, tau, dose, tinf, ...)

calc_ss_1cmt_linear_oral_0(tad, tau, dose, dur, ...)

calc_ss_1cmt_linear_oral_0_lag(tad, tau, dose, dur, ...)

calc_ss_1cmt_linear_oral_1_lag(tad, tau, dose, ...)

calc_ss_1cmt_linear_oral_1(tad, tau, dose, ...)

Arguments

• tad: Time after dose (h)
• tau: Dosing interval (h)
• dose: Dose
• dur: Duration of zero-order absorption (h)
• tinf: Duration of infusion (h)
• ...: Passed to calc_derived_1cpt()

Returns

Concentration of drug at requested time (t) after a single dose, given provided set of parameters and variables.

Functions

• calc_ss_1cmt_linear_bolus(): Calculate C(t) for a 1-compartment linear model with IV bolus dosing at steady state
• calc_ss_1cmt_linear_infusion(): Calculate C(t) for a 1-compartment linear model with infusion at steady state
• calc_ss_1cmt_linear_oral_0(): Calculate C(t) for a 1-compartment linear model with zero-order oral absorption at steady state
• calc_ss_1cmt_linear_oral_0_lag(): Calculate C(t) for a 1-compartment linear model with zero-order oral absorption at steady state, with lag time
• calc_ss_1cmt_linear_oral_1_lag(): Calculate C(t) for a 1-compartment linear model with first-order oral absorption at steady state, with lag time
• calc_ss_1cmt_linear_oral_1(): Calculate C(t) for a 1-compartment linear model with first-order oral absorption at steady state

Examples

Ct <- calc_ss_1cmt_linear_bolus(t=0:24, CL=6, V=25, dose=600, tau=24)
Ct <- calc_ss_1cmt_linear_infusion(tad=0:36, CL=2, V=25, dose=600, tinf=1, tau=24)
Ct <- calc_ss_1cmt_linear_oral_0(tad=0:36, CL=2, V=25, dose=600, dur=1, tau=24)
Ct <- calc_ss_1cmt_linear_oral_0_lag(tad=0:36, CL=2, V=25, dose=600, dur=1, tau=24, tlag=1.5)
Ct <- calc_ss_1cmt_linear_oral_1_lag(tad=0:36, CL=2, V=25, dose=600,
    ka=0.25, tlag=0.75, tau=24)
Ct <- calc_ss_1cmt_linear_oral_1(tad=0:36, CL=2, V=25, dose=600, ka=0.25, tau=24)

References

Bertrand J & Mentre F (2008). Mathematical Expressions of the Pharmacokinetic and Pharmacodynamic Models implemented in the Monolix software. http://lixoft.com/wp-content/uploads/2016/03/PKPDlibrary.pdf

Rowland M, Tozer TN. Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications (4th). Lippincott Williams & Wilkins, Philadelphia, 2010.

Author(s)

Justin Wilkins, justin.wilkins@occams.com

Bill Denney, wdenney@humanpredictions.com