GSD_allocation_seq function

Calculates the Type I error for a randomization sequence in a group sequential design

GSD_allocation_seq(sfu, K, seq, ui = "No")

Arguments

• sfu: Group sequential design used (currently available: "Pocock" - Pocock, "OF" - O'Brien & Fleming, sfLDPocock - Lan & DeMets with Pocock like alpha spending function, sfLDOF - Lan & DeMets with O'Brien & Fleming like alpha spending function)
• K: number of stages
• seq: List of consecutive treatment allocations. 1 for first treatment A, 2 for second treatment.
• ui: Only for Lan & DeMets design. Update critical values after each stage according to allocation ratio observed if set to "yes".

Returns

A list of type I error probabilities for each stage.

Examples

#Simulate a group sequential design according to Pocock's design with 24 patients
#and the following consecutive treatment allocation:
#A, A, B, A, A, B, A, B, A, B, A, B, A, B, A, B, B, B, A, B, B, A, B, B
GSD_allocation_seq(sfu ="Pocock", K=3, seq = c(1,1,0,1,1,0,1,1,1,0,1,0,1,0,1,0,0,0,1,0,0,1,0,0))
#Simulate a group sequential design according to Lan and DeMets with O'Brien & Fleming
#like alpha spending with 24 patients and the following consecutive treatment allocation:
#A, A, B, A, A, B, A, B, A, B, A, B, A, B, A, B, B, B, A, B, B, A, B, B
library(gsDesign)
GSD_allocation_seq(sfu =sfLDOF, K=3, seq = c(1,1,0,1,1,0,1,1,1,0,1,0,1,0,1,0,0,0,1,0,0,1,0,0))