randomizeR3.0.2 package

Randomization for Clinical Trials

a

Function returning the adjusting parameter a slot of an S4 object

abcdPar

Representing Accelerated Biased Coin Design

abcdRand

Sampling algorithm for abcd

analyse

Creates stratified sequences Compares stratified sequences to their re...

assess

Assessing randomization sequences

bbcdPar

Representing Bayesian Biased Coin Design

bbcdRand

Sampling algorithm for bbcd

blocks

Function returning the block slot of an S4 object

bsdPar

Representing Big Stick Design

bsdRand

Sampling algorithm for BSD

cash-assessment-method

Method defining the $ operator for the assessment class

cash-comparison-method

Method defining the $ operator for the assessment class

cash-derFunc-method

Method defining the $ operator for the derFunc class

cash-desFunc-method

Method defining the $ operator for the desFunc class

cash-desScores-method

Method defining the $ operator for the assessment class

cash-endpoint-method

Method defining the $ operator for the endpoint class

cash-evaluation-method

Method defining the $ operator for the evaluation class

cash-issue-method

Method defining the $ operator for the issue class

cash-probUnDesirable-method

Method defining the $ operator for the probUnDesirable class

cash-randPar-method

Method defining the $ operator for the randPar class

cash-randSeq-method

Method defining the $ operator for the randSeq class

chenPar

Representing Chen's Design

chenRand

Representing Chen's Design

chronBias

Representing chronological bias

coin

Function returning the coin slot of an S4 object

combineBias

Combined bias criterion

compare

Comparison of randomization procedures

corGuess

Representing the expected number of correct guesses

createParam

Representing any randomization procedure

createSeq

Query to create a randomization sequence of a particular randomization...

crPar

Representing Complete Randomization

derFunc

Representing Derringer-Suich desirability functions

desirability

Desirability functions within the scope of clinical trials

doublyF_opt

Distribution function of the non central F-distribution

doublyF_value

Rejection probability for one sequence in the presence of selection bi...

doublyF_values

Rejection probability in case of selection bias in multi-arm trials

doublyT

Approximation of the distribution function of the doubly noncentral t-...

doublyTValues

Calculation of the biased type-one-error probability (resp. power) of ...

ebcPar

Representing Efron's Biased Coin Design

evaluate

Evaluation of several randomization procedures with respect to certain...

expEndp

Representation of exponentially distributed endpoints

gbcdPar

Representing Generalized Biased Coin Design

gbcdRand

Sampling algorithm for gbcd

generateAllSequences

Complete set of randomization sequences

generateRandomSequences

Generate random sequences

genNcps

Calculation of the NCPs of each randomization sequence for the doubly ...

genNcps_new

Calculation of the NCPs of each randomization sequence for the doubly ...

get_p_values_new

Calculating p values

getbiasCS1

Biasing Policy for a Group of Favored Treatments

getbiasCS2

Biasing Policy for Avoiding the Placebo Treatment

getCorGuesses

Matrix of the guesses of the investigator

getDesFunc

Type of Desirability function

getDesign

Design of a randomization procedure

getDesScores

Applying desirability functions on issues of individual randomization ...

getDistributionPars

Get distribution parameters of a randomization list

getExpectation

Get expectations of a randomization list

getProbabilities

Theoretical probability for randomization sequences

getRandomizationList

Accessor function for the randomization list

GSD_allocation

Calculates the Type I error for different randomization sequences from...

GSD_allocation_seq

Calculates the Type I error for a randomization sequence in a group se...

hadaPar

Representing Hadamard Randomization

hasAllGroups

Check function for occurrence of all treatment groups in the sequence

hatMatrix

Calculate hat matrix

imbal

Representing the allocation imbalance

issue

Assessment criteria for clinical trials

K

Function returning the number of trial arms slot of an S4 object

lambda

Method returning the rate parameter of an expEndp S4 object

lambda1

Calculate first non centrality parameter of the doubly non central F-d...

lambda2

Calculate second non centrality parameter of the doubly non central F-...

logRankDecSim

logRankDecSim

logRankRejectionProb

Approximation of the biased type I error probability (resp. power) of ...

makeBiasedExpectation

Calculate Expectation vector

makeDesignMatrix

Design Matrix

method

Function returning the method of an S4 object

mpPar

Representing Maximal Procedure

mti

Function returning the MTI slot of an S4 object

mu

Access the expectation value slot of a normEndp S4 object

N

Function returning the sample size slot of an S4 object

normEndp

Representation of normally distributed endpoints

overview

Overview over the parameters used in the randomizeR package

pbrPar

Representing Permuted Block Randomization

plot

Generic plotting of comparison objects

plotDes

desScore plotting

plotEv

Evaluation plotting

plotSeq

Sequence plotting

probUnDes

Computing the probability of having desirability scores of zero

randBlocks

Function returning the block slot of an S4 object

randomizeR-package

Randomization for Clinical Trials

randPar

Settings for randomization procedures

randSeq-class

An S4 Class for the representation of randomization sequences

rarPar

Representing Random Allocation Rule

ratio

Function returning the allocation ratio slot of an S4 object

rho

Function returning the adjusting parameter rho slot of an S4 object

rpbrPar

Representing Randomized Permuted Block Randomization

rtbdPar

Representing Randomized Truncated Binomial Design

saveAssess

Saving an assess object

saveRand

Saving a randomization lists

scale

Method returning the scale parameter of an survEndp S4 object

seed

Function returning the allocation seed slot of an object

selBias

Representing selection bias

setPower

Representing the power

shape

Method returning the shape parameter of an survEndp S4 object

sigma

Function returning the standard deviation slot of a normEndp S4 object

summary

Summary of assessments of a randomization procedure

survEndp

Representation of survival endpoints

tbdPar

Representing Truncated Binomal Design

TV

Function returning the target value slot of an S4 object

type

Get type of an object

udPar

Representing Wei's Urn Design

This tool enables the user to choose a randomization procedure based on sound scientific criteria. It comprises the generation of randomization sequences as well the assessment of randomization procedures based on carefully selected criteria. Furthermore, 'randomizeR' provides a function for the comparison of randomization procedures.

  • Maintainer: Ralf-Dieter Hilgers
  • License: GPL (>= 3)
  • Last published: 2023-09-18