bsdPar function

Representing Big Stick Design

Represents the randomization procedure Big Stick Design.

bsdPar(N, mti, groups = LETTERS[1:2])

Arguments

• N: integer for the total sample size of the trial.
• mti: maximum tolerated imbalance in patient numbers during the trial.
• groups: character vector of labels for the different treatments.

Returns

S4 object of the class bsdPar.

Details

Tossing a fair coin as long as the difference in group sizes does not exceed the mti. If the mti is reached a deterministic allocation is done, so that the difference in group sizes is reduced.

References

J. F. Soares and C. F. Jeff Wu (1983) Some Restricted Randomization Rules in Sequential Designs. Comm. in Stat., 12 , 2017-34.

See Also

Other randomization procedures: abcdPar, bbcdPar, chenPar, crPar, createParam(), ebcPar, gbcdPar, hadaPar, mpPar, pbrPar, rarPar, rpbrPar, rtbdPar, tbdPar, udPar