mpPar function

Representing Maximal Procedure

Represents the Maximal Procedure.

mpPar(N, mti, ratio = c(1, 1), groups = LETTERS[1:2])

Arguments

• N: integer for the total sample size of the trial.
• mti: maximum tolerated imbalance in patient numbers during the trial.
• ratio: vector of length K. The total sample number N and all used block lengths (bc) have to be divisible by sum(ratio).
• groups: character vector of labels for the different treatments.

Returns

S4 object of the class mpPar.

Details

Fix the total sample size N and the mti. Afterwards, the patients are assigned to each treatment arm according to the ratio. All randomization sequences are equiprobable.

References

V.W. Berger, A. Ivanova and M.D. Knoll (2003) Minimizing predictability while retaining balance through the use of less restrictive randomization procedures. Statistics in Medicine, 19 , 3017-28.

See Also

Other randomization procedures: abcdPar, bbcdPar, bsdPar, chenPar, crPar, createParam(), ebcPar, gbcdPar, hadaPar, pbrPar, rarPar, rpbrPar, rtbdPar, tbdPar, udPar