chenRand function

Representing Chen's Design

chenRand(N, mti, p, K = 2)

Arguments

• N: integer for the total sample size of the trial.
• mti: maximum tolerated imbalance in patient numbers during the trial.
• p: success probability of the biased coin (e.g. in Efron's Biased Coin Design).
• K: number of treatment groups (e.g. K=2 if we compare one experimental against one control treatment).

Returns

A vector with the allocation sequence for a clinical trial. It will contain a zero (resp. 1) at position i, when patient i

is allocated to treatment A (resp. B).

References

Chen Yung-Pin (1999) Biased coin design with imbalance tolerance. Comm. in Stat., 15, 953-975.