Represents the randomization procedure Bayesian Biased Coin Design.
bbcdPar(N, a, groups = LETTERS[1:2])
Arguments
N: integer for the total sample size of the trial.
a: nonnegative parameter which controls the degree of randomness: For decreasing a the allocations become deterministic, while for increasing a the randomization procedure tends to complete randomization.
groups: character vector of labels for the different treatments.
Returns
S4 object of the class bbcdPar.
Details
Extension of Efron's biased coin design.
References
A. B. Antognini and Maroussa Zagoraiou (2014) Balance and randomness in sequential clinical trials: the dominant biased coin design. Pharmaceutical Statistics