Spectral Clustering-Based Method for Identifying B Cell Clones
Hierarchical clustering method for clonal partitioning
Sequence identity method for clonal partitioning
Plot clonal clustering summary
scoper: Spectral Clustering-Based Method for Identifying B Cell Clones
The SCOPer package
S4 class containing clonal assignments and summary data
Spectral clustering method for clonal partitioning
Provides a computational framework for identification of B cell clones from Adaptive Immune Receptor Repertoire sequencing (AIRR-Seq) data. Three main functions are included (identicalClones, hierarchicalClones, and spectralClones) that perform clustering among sequences of BCRs/IGs (B cell receptors/immunoglobulins) which share the same V gene, J gene and junction length. Nouri N and Kleinstein SH (2018) <doi: 10.1093/bioinformatics/bty235>. Nouri N and Kleinstein SH (2019) <doi: 10.1101/788620>. Gupta NT, et al. (2017) <doi: 10.4049/jimmunol.1601850>.