ubiquity2.0.3 package

PKPD, PBPK, and Systems Pharmacology Modeling Tools

apply_sub_file_COV

Extracts Covariates for a Subject from a Subject Data File

archive_estimation

Archive Estimation Results

AUC_Bailers_method

Calculate AUC for Sparse Data

build_system

Build the System File

calculate_halflife

Calculate the halflife of data

calculate_objective

Calculates the Value of the Specified Objective Function

calculate_objective_ga

GA Wrapper for calculate_objective

calculate_objective_pso

pso Wrapper for calculate_objective

calculate_variance

Calculates the Variance in od_general

check_steady_state

Verify System Steady State

compare_estimate

Compares Estimate to Bounds

estimate_parameters

Performs parameter estimation

fetch_full_parameters

Create Full Parameter Vector from Estimation Subset

find_bracketed_arguments

Parse Prototype Functions for Arguments

generate_parameter

Generates a Parameter Based on <IIV:?> in the System File

generate_report

Generate Text Report with Estimation Results

generate_subject

Generate Subject

gg_axis

Make Pretty ggplot x- or y-Axis Log 10 Scale

gg_log10_xaxis

Make Pretty ggplot x-Axis Log 10 Scale

gg_log10_yaxis

Make Pretty ggplot y-Axis Log 10 Scale

GUI_log_entry

Wrapper for system_log_entry Used in ShinyApp

linspace

Implementation of the linspace Function from Matlab

logspace

Implementation of the logspace Function from Matlab

make_forcing_function

Makes Forcing Function From Times and Values

nm_select_records

Select Records from NONMEM-ish Data Set

pad_string

Pad String with Spaces

parse_patterns

Parse String for Prototype Functions

prepare_figure

Make ggplot Figure Pretty

run_simulation_titrate

Simulate With Titration or Rule-Based Inputs

run_simulation_ubiquity

Simulate Individual Response

sample_around

Define Sample Times Around Events

simulate_subjects

Run Population Simulations

solution_statistics

Calculate Solution Statistics

som_to_df

Converts the Wide/Verbose Output Simulation Functions into Data Frames

system_check_requirements

Check For Perl and C Tools

system_check_steady_state

Verify System Steady State

system_clear_cohorts

Clear all Cohorts

system_define_cohort

Define Estimation Cohort

system_define_cohorts_nm

Define Cohorts from NONMEM Input File

system_estimate_parameters

Control Estimation Process

system_fetch_guess

Fetch Current Parameter Guesses

system_fetch_iiv

Fetch Variability Terms

system_fetch_nca

Fetch NCA Results

system_fetch_nca_columns

Columns in NCA Analysis

system_fetch_parameters

Fetch System Parameters

system_fetch_rpt_officer_object

Extracts the officer Object From the Specified ubiquity Report

system_fetch_rpt_onbrand_object

Extracts the onbrand Object From the Specified ubiquity Report

system_fetch_set

Fetch Mathematical Set

system_fetch_template

Create New Analysis Template

system_fetch_TSsys

Fetch System Timescale

system_glp_init

Initialize GLP study design

system_glp_scenario

Design GLP Study For a Scenario

system_load_data

Loading Datasets

system_log_debug_save

Save variables to files

system_log_entry

Add Log Entry

system_log_init

Initialize System Log File

system_nca_parameters_meta

List NCA parameters, text names and descriptions

system_nca_run

Automatic NCA

system_nca_summary

Summarize NCA Results in Tabular Format

system_new

Create New system.txt File

system_new_list

Fetch List of Available System Templates

system_new_tt_rule

Titration Rules

system_nm_check_ds

Check NONMEM Dataset for Automatic Definitions

system_od_general

General Observation Details Function

system_plot_cohorts

Plot Estimation Results

system_req

Require Suggested Packages

system_rpt_add_doc_content

Adds Content to a Word Report

system_rpt_add_slide

Add Slide to a Powerpoint Report

system_rpt_estimation

Generate a Report from Parameter Estimation

system_rpt_nca

Report NCA

system_rpt_read_template

Initialize a New Report

system_rpt_save_report

Save Report to a File

system_rpt_template_details

Generate Details about Report Template

system_select_set

Selecting Parameter Sets

system_set_bolus

Set Bolus Inputs

system_set_covariate

Set Covariate Values

system_set_guess

Alter Initial Guess and Parameter Bounds

system_set_iiv

Set Variability Terms

system_set_option

Setting Analysis Options

system_set_parameter

Set Value for Parameter

system_set_rate

Set Infusion Rate Inputs

system_set_rpt_officer_object

Sets the officer Object for the Specified ubiquity Report

system_set_rpt_onbrand_object

Sets the onbrand Object for the Specified ubiquity Report

system_set_tt_bolus

Actual Function Called by SI_TT_BOLUS

system_set_tt_cond

Define Titration Triggers and Actions

system_set_tt_rate

Actual Function Called by SI_TT_RATE

system_simulate_estimation_results

Simulate Results at Estimates

system_ts_to_simtime

Convert Time in Timescale to Simulation Time

system_view

View Information About the System

system_zero_inputs

Zero All Model Inputs

tic

Implementation of Matlab tic() command

timecourse_stats

Calculate Timecourse Statistics for a Matrix of Responses

toc

Implementation of Matlab toc() command

ubiquity_name_check

Check Names of Cohorts, Analyses, Reports, etc.

var2string

Converts Numeric Variables into Padded Strings

var2string_gen

Convert R Objects to Strings

vp

Print and Log Messages

workshop_fetch

Fetch Ubiquity Workshop Sections

Complete work flow for the analysis of pharmacokinetic pharmacodynamic (PKPD), physiologically-based pharmacokinetic (PBPK) and systems pharmacology models including: creation of ordinary differential equation-based models, pooled parameter estimation, individual/population based simulations, rule-based simulations for clinical trial design and modeling assays, deployment with a customizable 'Shiny' app, and non-compartmental analysis. System-specific analysis templates can be generated and each element includes integrated reporting with 'PowerPoint' and 'Word'.

  • Maintainer: John Harrold
  • License: BSD_2_clause + file LICENSE
  • Last published: 2024-03-08