Diagnostics for Nonlinear Mixed-Effect Models
Absolute conditional weighted residuals vs covariates for Xpose 4
Absolute value of the conditional weighted residuals vs. population pr...
Absolute population conditional weighted residuals vs population predi...
Absolute population weighted residuals vs population predictions, and ...
box and whisker plots of the absolute value of the individual weighted...
absolute value of the individual weighted residuals vs. the independen...
Absolute individual weighted residuals vs individual predictions, cond...
Absolute individual weighted residuals vs individual predictions for X...
Absolute individual weighted residuals vs population predictions or in...
Absolute weighted residuals vs covariates for Xpose 4
Absolute value of (C)WRES vs. independent variable plot in Xpose4.
Absolute population weighted residuals vs population predictions, cond...
Absolute population weighted residuals vs population predictions for X...
Model comparison plots, of absolute differences in goodness-of-fit pre...
Print tables or text in a grid object
Additional model comparison plots, for Xpose 4
Column-transformation functions for Xpose 4
Generic internal functions for Xpose 4
Additional goodness-of-fit plots, for Xpose 4
Autocorrelation of conditional weighted residuals for Xpose 4
autocorrelation of the individual weighted residuals
Autocorrelation of weighted residuals for Xpose 4
Basic goodness-of-fit plots, for Xpose 4
Basic model comparison plots, for Xpose 4
Function to create histograms of results from the bootstrap tool in ...
Print summary information for a bootgam or bootscm
Import bootscm data into R/Xpose
Categorical observations vs. independent variable using stacked bars.
Categorical (visual) predictive check.
Generic table functions for Xpose 4
Change parameter scope.
Changes the name of an Xpose data item
Changes the label of an Xpose data item
Change Xpose variable definitions.
Functions changing variable definitions in Xpose 4
Functions changing miscellaneous parameter settings in Xpose 4
Data functions for Xpose 4
Compute the Conditional Weighted Residuals
Function to create mirror plots from the generic Xpose plotting comman...
Create xpose.multiple.plot class.
This function creates the Xpose data classes ("xpose.data" and "xpose....
Histogram of conditional weighted residuals (CWRES), for Xpose 4
Quantile-quantile plot of conditional weighted residuals (CWRES), for ...
Conditional Weighted residuals (CWRES) plotted against covariates, for...
Box-and-whisker plot of conditional weighted residuals vs the independ...
Population conditional weighted residuals (CWRES) plotted against the ...
Box-and-whisker plot of conditional weighted residuals vs population p...
Population conditional weighted residuals (CWRES) plotted against popu...
Weighted residuals (WRES) and conditional WRES (CWRES) plotted against...
Weighted residuals (WRES) and conditional WRES (CWRES) plotted against...
Check through the source dataset to detect problems
Extract or assign data from an xpose.data object.
Prints the contents of an Xpose data object
Change in individual objective function value vs. covariate value.
Change in Objective function value vs. removal of individuals.
Change in individual objective function value 1 vs. individual objecti...
Observations (DV), individual predictions (IPRED) and population predi...
Observations (DV) plotted against the independent variable (IDV) for X...
Dependent variable vs individual predictions, conditioned on covariate...
Dependent variable vs individual predictions, conditioned on independe...
Observations (DV) plotted against individual predictions (IPRED) for X...
Dependent variable vs population predictions, conditioned on covariate...
Dependent variable vs population predictions, conditioned on independe...
Observations (DV) are plotted against individual predictions (IPRED) a...
Observations (DV) plotted against population predictions (PRED) for Xp...
Extract and set Xpose variable definitions.
Exports Xpose graphics settings to a file.
Exports Xpose variable definitions to a file from an Xpose data object...
Internal functions for the VPC
GAM functions for Xpose 4
Structured goodness of fit diagnostics.
Imports Xpose graphics settings from a file to an Xpose data object.
Imports Xpose variable definitions from a file to an Xpose data object...
Observations (DV), individual predictions (IPRED) and population predi...
Histograms of weighted residuals for each individual in an Xpose data ...
Quantile-quantile plots of weighted residuals for each individual in a...
Individual predictions (IPRED) plotted against the independent variabl...
Histogram of individual weighted residuals (IWRES), for Xpose 4
Quantile-quantile plot of individual weighted residuals (IWRES), for X...
Individual weighted residuals (IWRES) plotted against the independent ...
Kaplan-Meier plots of (repeated) time-to-event data
Make stacked bar data set.
Function to plot the coverage of the Numerical Predictive Check
Extract or set the value of the Nsim slot.
Plot the parameter or covariate distributions using a histogram
Plot the parameter or covariate distributions using quantile-quantile ...
Plot scatterplot matrices of parameters, random parameters or covariat...
Summarize individual parameter values and covariates
Parameters plotted against covariates, for Xpose 4
Plot parameters vs other parameters
Population predictions (PRED) plotted against the independent variable...
Print an Xpose multiple plot object.
Function to create a histogram of results from the randomization test ...
Random parameters plotted against covariates, for Xpose 4
Reading NONMEM table files
Read the results file from a Numerical or Visual Predictive Check run ...
Read (repeated) time-to-event simulation data files.
Read the vpctab file from PsN into Xpose
Read NONMEM output files into Xpose 4
Read NONMEM table files produced from simulation.
Resets Xpose variable definitions to factory settings
Print run summary in Xpose 4
Function to create files for the simulated prazosin example in Xpose
Tabulate the population parameter estimates
Histogram of weighted residuals (WRES), for Xpose 4
Quantile-quantile plot of weighted residuals (WRES), for Xpose 4
Weighted residuals (WRES) plotted against covariates, for Xpose 4
Box-and-whisker plot of weighted residuals vs the independent variable...
Population weighted residuals (WRES) plotted against the independent v...
Box-and-whisker plot of weighted residuals vs population predictions f...
Population weighted residuals (WRES) plotted against population predic...
Extract and set labels for Xpose data items.
Correlations between covariate coefficients
Compare parameter estimates for covariate coefficients
Distribution of difference in AIC
Plot of model size distribution for a bootgam or bootscm
Distribution of difference in OFV
OFV difference (optimism) plot.
Default function for calculating dispersion in xpose.gam.
Trace plots for conditional indices
Trace plots for conditional indices rper replicate number
Inclusion frequency plot for combination of covariates.
Inclusion frequency plot
Inclusion stability plotA plot of the inclusion frequency of covariate...
Inclusion index individuals, compare between covariates.
Individual inclusion index
Plot of inclusion index of covariates.
Define a scope for the gam. Used as default input to the scope argum...
Function to ask the user for the name of a file
Title
Functions to create labels for plots
Create Xpose title text for plots.
Class xpose.data
Create an Xpose data object
Create a new graphical device for an Xpose plot.
Stepwise GAM search for covariates on a parameter (Xpose 4)
Displays the Xpose license and citation information
Class for creating multiple plots in xpose
Xpose 4 generic function for plotting multiple lattice objects on one ...
Create and object with class "xpose.multiple.plot".
Default box-and-whisker panel function for Xpose 4
Default panel function for Xpose 4
Default histogram panel function for Xpose 4
Default QQ panel function for Xpose 4
Scatterplot matrix panel function for Xpose 4
The generic Xpose functions for box-and-whisker plots
The Xpose 4 generic functions for continuous y-variables.
The Xpose 4 generic functions for continuous y-variables.
The generic Xpose functions for QQ plots
The Xpose 4 generic functions for scatterplot matrices.
Class "xpose.prefs"
Summarize an xpose database
Print a pretty string.
Xpose Visual Predictive Check (VPC) for both continuous and Limit of Q...
Xpose visual predictive check for categorical data.
Visual Predictive Check (VPC) using XPOSE
Functions to create nice looking axes when using Log scales.
The Xpose Package
Classic menu system for Xpose 4
Extract or set the value of the Subset slot.
A model building aid for nonlinear mixed-effects (population) model analysis using NONMEM, facilitating data set checkout, exploration and visualization, model diagnostics, candidate covariate identification and model comparison. The methods are described in Keizer et al. (2013) <doi:10.1038/psp.2013.24>, and Jonsson et al. (1999) <doi:10.1016/s0169-2607(98)00067-4>.
Useful links