Analysis of Sex Differences in Omics Data for Complex Diseases
Internal function call_sr
Compute sex-specific differentially expressed genes (DEGs) per categor...
Perform Pathway Enrichment Analysis for Pre-Categorized Differentially...
Construct Protein-protein interaction Network using Prize-Collecting S...
Convert Data Frame to enrichResult
Generate Boxplots for Expression Data
Generate a Comprehensive Analysis Report
Generate a Comprehensive Analysis Report
Download and Process STRING Protein-Protein Interaction Network
Identify sex-specific and sex-dimorphic genes
Improved Pathway Enrichment Analysis
Prize-collecting Steiner Forest (PCSF)
Plot a Condition-Specific protein-protein interaction network with DEG...
Perform Sex-Phenotype Interaction Analysis for Bulk Data (Interaction ...
Perform Sex-Phenotype Interaction Analysis for Single-Cell Data
Perform differential expression analysis within each sex
Compute sex-specific differentially expressed genes (DEGs)
Visualize Gene Regulatory Network with Pie Charts
XYomics: Analysis of Sex Differences in Omics Data
Tools to analyze sex differences in omics data for complex diseases. It includes functions for differential expression analysis using the 'limma' method <doi:10.1093/nar/gkv007>, interaction testing between sex and disease, pathway enrichment with 'clusterProfiler' <doi:10.1089/omi.2011.0118>, and gene regulatory network (GRN) construction and analysis using 'igraph'. The package enables a reproducible workflow from raw data processing to biological interpretation.