qch2.1.0 package

Query Composite Hypotheses

Copula.Hconfig_gaussian_density

Gaussian copula density for each H-configuration.

EM_calibration_gaussian_memory

EM calibration in the case of the Gaussian copula (unsigned) with memo...

EM_calibration_gaussian

EM calibration in the case of the Gaussian copula (unsigned)

EM_calibration_indep_memory

EM calibration in the case of conditional independence with memory man...

EM_calibration_indep

EM calibration in the case of conditional independence

f1_separation_signed

Signed case function: Separate f1 into f+ and f-

FastKerFdr_signed

FastKerFdr signed

FastKerFdr_unsigned

FastKerFdr unsigned

fHconfig_sum_update_gaussian_copula_ptr_parallel

Computation of the sum sum_c(w_c*psi_c) using Gaussian copula parallel...

fHconfig_sum_update_ptr_parallel

Computation of the sum sum_c(w_c*psi_c) parallelized version

gaussian_copula_density

Gaussian copula density

GetH1AtLeast

Specify the configurations corresponding to the composite H1H_1 test "...

GetH1Equal

Specify the configurations corresponding to the composite H1H_1 test "...

GetHconfig

Generate the H0H_0/H1H_1 configurations.

prior_update_arma_ptr_parallel

Update of the prior estimate in EM algo parallelized version

prior_update_gaussian_copula_ptr_parallel

Update of the prior estimate in EM algo using Gaussian copula, paralle...

qch-package

qch: Query Composite Hypotheses

qch.fit

Infer posterior probabilities of H0H_0/H1H_1 configurations.

qch.test

Perform composite hypothesis testing.

R_MLE_update_gaussian_copula_ptr_parallel

Update the estimate of R correlation matrix of the gaussian copula, pa...

R.MLE.check

Check the Gaussian copula correlation matrix Maximum Likelihood estima...

R.MLE.memory

Gaussian copula correlation matrix Maximum Likelihood estimator (memor...

R.MLE

Gaussian copula correlation matrix Maximum Likelihood estimator.

Provides functions for the joint analysis of Q sets of p-values obtained for the same list of items. This joint analysis is performed by querying a composite hypothesis, i.e. an arbitrary complex combination of simple hypotheses, as described in Mary-Huard et al. (2021) <doi:10.1093/bioinformatics/btab592> and De Walsche et al.(2023) <doi:10.1101/2024.03.17.585412>. In this approach, the Q-uplet of p-values associated with each item is distributed as a multivariate mixture, where each of the 2^Q components corresponds to a specific combination of simple hypotheses. The dependence between the p-value series is considered using a Gaussian copula function. A p-value for the composite hypothesis test is derived from the posterior probabilities.

  • Maintainer: Tristan Mary-Huard
  • License: GPL-3
  • Last published: 2025-07-04