Relationship Inference for DNA Mixtures
Find all possible genotypes
Load and check a frequency file
Load and check a mixture file
Check a pedigree file
Check a reference profiles file
Create data matrix with possible genotype combinations for specified i...
Create a mixture of genotypes with simulated drop-in and dropout
Likelihoods for DNA mixtures with dropout and dropin
Relationship inference based on mixtures
GUI for relMix
Analysis of DNA mixtures involving relatives by computation of likelihood ratios that account for dropout and drop-in, mutations, silent alleles and population substructure. This is useful in kinship cases, like non-invasive prenatal paternity testing, where deductions about individuals' relationships rely on DNA mixtures, and in criminal cases where the contributors to a mixed DNA stain may be related. Relationships are represented by pedigrees and can include kinship between more than two individuals. The main function is relMix() and its graphical user interface relMixGUI(). The implementation and method is described in Dorum et al. (2017) <doi:10.1007/s00414-016-1526-x>, Hernandis et al. (2019) <doi:10.1016/j.fsigss.2019.09.085> and Kaur et al. (2016) <doi:10.1007/s00414-015-1276-1>.