AntibodyForests1.1.0 package

Delineating Inter- And Intra-Antibody Repertoire Evolution

Af_add_node_feature

Function to add node features to an AntibodyForests-object

Af_build

Function to infer B cell evolutionary networks for all clonotypes in V...

Af_cluster_metrics

Function to make a grouped boxplot of metrics from clusters of clonoty...

Af_cluster_node_features

Function to create a barplot of the cluster composition of selected fe...

Af_compare_across_repertoires

A function to compare dynamics of B cell evolution across different re...

Af_compare_methods

Function to compare trees created with different algorithms from the s...

Af_compare_PLM

Function to compare the distributions of the Protein Language Model pr...

Af_compare_within_repertoires

Function to compare tree topology of B cell lineages

Af_distance_boxplot

Function to make a grouped boxplot of distance between nodes from spec...

Af_distance_scatterplot

Function to scatterplot the distance to the germline to a numerical no...

Af_edge_RMSD

Function to calculate the RMSD between sequences over each edge in the...

Af_get_sequences

Function to get the sequences from the nodes in an AntibodyForest obje...

Af_metrics

Function to calculate metrics for each tree in an AntibodyForests-obje...

Af_node_size_boxplot

Function to make a grouped boxplot of the normalized average node size...

Af_PLM_dataframe

Function to create a dataframe of the Protein Language Model probabili...

Af_plot_PLM_mut_vs_cons

Function to create a boxplot of the Protein Language Model probabiliti...

Af_plot_PLM

Function to create a distribution plot of the Protein Language Model p...

Af_plot_tree

Plots lineage tree of clonotype from AntibodyForests object

Af_sync_nodes

Function to synchronize the node labels/names of all clonotypes within...

Af_to_newick

Saves an AntibodyForests-object into a newick file

calculate_GBLD

Calculate the GBLD distance between trees in an AntibodyForests object...

igraph_to_phylo

Converts an igraph network into a phylogenetic tree as a phylo object.

newick_to_Af

Converts files with phylogenetic trees in newick format into an Antibo...

VDJ_3d_properties

Function to calculate 3D-structure propoperties such as the average ch...

VDJ_import_IgBLAST_annotations

Function to import the annotations and alignments from IgBLAST output ...

VDJ_integrate_bulk

A function to integrate bulk and single cell data

VDJ_to_AIRR

Function to convert VDJ dataframe into an AIRR-formatted TSV file.

The generated wealth of immune repertoire sequencing data requires software to investigate and quantify inter- and intra-antibody repertoire evolution to uncover how B cells evolve during immune responses. Here, we present 'AntibodyForests', a software to investigate and quantify inter- and intra-antibody repertoire evolution.

  • Maintainer: Daphne van Ginneken
  • License: GPL-2
  • Last published: 2025-07-17