Proteomics Data Analysis and Modeling Tools
Filter proteins by group level missing data
Compute average intensity
Correlation between technical replicates
Create a data frame of protein intensities
Visualize feature (protein) variation among conditions
Identify differentially expressed proteins between groups
Heatmap of differentially expressed proteins
Visualize missing data
Impute missing values
Visualize the impact of imputation
Visualize the effect of normalization
Normalize intensity data
Proteins that are only expressed in a given group
Model performance plot
Pre-process protein intensity data for modeling
Remove user-specified proteins (features) from a data frame
Remove user-specified samples
ROC plot
Split the data frame to create training and test data
Test machine learning models on test data
Train machine learning models on training data
Variable importance plot
Volcano plot
A comprehensive, user-friendly package for label-free proteomics data analysis and machine learning-based modeling. Data generated from 'MaxQuant' can be easily used to conduct differential expression analysis, build predictive models with top protein candidates, and assess model performance. promor includes a suite of tools for quality control, visualization, missing data imputation (Lazar et. al. (2016) <doi:10.1021/acs.jproteome.5b00981>), differential expression analysis (Ritchie et. al. (2015) <doi:10.1093/nar/gkv007>), and machine learning-based modeling (Kuhn (2008) <doi:10.18637/jss.v028.i05>).
Useful links