Weighted Correlation Network Analysis
Accuracy measures for a 2x2 confusion matrix or for vectors of predict...
Add error bars to a barplot.
Add grid lines to an existing plot.
Add vertical ``guide lines'' to a dendrogram plot
Add trait information to multi-set module eigengene structure
Adjacency matrix based on polynomial regression
Calculate network adjacency
Calculate network adjacency based on natural cubic spline regression
Prediction of Weighted Mutual Information Adjacency Matrix by Correlat...
Align expression data with given vector
Divide tasks among workers
Allow and disable multi-threading for certain WGCNA calculations
One-step automatic network gene screening
One-step automatic network gene screening with external gene significa...
Various basic operations on BlockwiseData
objects.
Biweight Midcorrelation
Calculation of biweight midcorrelations and associated p-values
Weights used in biweight midcovariance
Turn categorical columns into sets of binary indicators
Turn a categorical variable into a set of binary indicators
Attempt to calculate an appropriate block size to maximize efficiency ...
Find consensus modules across several datasets.
Calculation of block-wise topological overlaps
Automatic network construction and module detection
Blue-white-red color sequence
Branch dissimilarity based on eigennodes (eigengenes).
Branch split based on dissimilarity.
Branch split.
Branch split (dissimilarity) statistics derived from labels determined...
Check adjacency matrix
Check structure and retrieve sizes of a group of datasets.
Chooses a single hub gene in each module
Chooses the top hub gene in each module
Clustering coefficient calculation
Permutation test for co-clustering
Co-clustering measure of cluster preservation between two clusterings
Select one representative row per group
Selects one representative row per group based on kME
Iterative garbage collection.
Fast colunm- and row-wise quantile of a matrix.
Calculation of conformity-based network concepts.
Conformity and module based decomposition of a network adjacency matri...
Calculation of a (single) consenus with optional data calibration.
Consensus clustering based on topological overlap and hierarchical clu...
Calculate consensus kME (eigengene-based connectivities) across multip...
Consensus dissimilarity of module eigengenes.
Put close eigenvectors next to each other in several sets.
Consensus projective K-means (pre-)clustering of expression data
Consensus selection of group representatives
Consensus network (topological overlap).
Get all elementary inputs in a consensus tree
Convert character columns that represent numbers to numeric
Fast calculations of Pearson correlation.
Calculation of correlations and associated p-values
Qunatification of success of gene screening
Fisher's asymptotic p-value for correlation
Student asymptotic p-value for correlation
Preservation of eigengene correlations
Deviance- and martingale residuals from a Cox regression model
Constant-height tree cut
Constant height tree cut using color labels
Show colors used to label modules
Threshold for module merging
Empirical Bayes-moderated adjustment for unwanted covariates
Export network to Cytoscape
Export network data in format readable by VisANT
Turn non-numeric columns into factors
Put single-set data into a form useful for multiset calculations.
Break long character strings into multiple lines
Calculation of fundamental network concepts from an adjacency matrix.
Calculation of GO enrichment (experimental)
Filter genes with too many missing entries
Filter genes with too many missing entries across multiple sets
Filter samples with too many missing entries
Iterative filtering of samples and genes with too many missing entries
Iterative filtering of samples and genes with too many missing entries...
Filter samples with too many missing entries across multiple data sets
Green-black-red color sequence
Green-white-red color sequence
Generalized Topological Overlap Measure
Hierarchical consensus calculation
Calculation of measures of fuzzy module membership (KME) in hierarchic...
Hierarchical consensus calculation of module eigengene dissimilarity
Hierarchical consensus network construction and module identification
Calculation of hierarchical consensus topological overlap matrix
Merge close (similar) hierarchical consensus modules
Hubgene significance
Impute missing data separately in each module
Calculate individual correlation network matrices
Inline display of progress
Calculation of intramodular connectivity
Determine whether the supplied object is a valid multiData structure
Keep probes that are shared among given data sets
Function to plot kME values between two comparable data sets.
Barplot with text or color labels.
Labeled heatmap divided into several separate plots.
Produce a labeled heatmap plot
Label scatterplot points
Convert numerical labels to colors.
Convert a list to a multiData structure and vice-versa.
Reconstruct a symmetric matrix from a distance (lower-triangular) repr...
Relabel module labels to best match the given reference labels
Construct a network from a matrix
Merge close modules in gene expression data
Meta-analysis of binary and continuous variables
Meta-analysis Z statistic
Fast joint calculation of row- or column-wise minima and indices of mi...
Modified Bisquare Weights
Get the prefix used to label module eigengenes.
Calculate module eigengenes.
Merge modules and reassign genes using kME.
Fixed-height cut of a dendrogram.
Calculation of module preservation statistics
Apply a function to each set in a multiData structure.
Apply a function to elements of given multiData structures.
Turn a multiData structure into a single matrix or data frame.
Set attributes on each component of a multiData structure
Get and set column names in a multiData structure.
If possible, simplify a multiData structure to a 3-dimensional array.
Subset rows and columns in a multiData structure
Eigengene significance across multiple sets
Create a multiData structure.
Analogs of grep(l) and (g)sub for multiple patterns and relacements
Calculate module eigengenes.
Union and intersection of multiple sets
Calculate weighted adjacency matrices based on mutual information
Nearest centroid predictor
Connectivity to a constant number of nearest neighbors
Connectivity to a constant number of nearest neighbors across multiple...
Calculations of network concepts
Identification of genes related to a trait
Network gene screening with an external gene significance measure
Create a list holding information about dividing data into blocks
Create, merge and expand BlockwiseData objects
Create a list holding consensus calculation options.
Create a new consensus tree
Creates a list of correlation options.
Create a list of network construction arguments (options).
Transform numerical labels into normal order.
Number of present data entries.
Number of sets in a multi-set variable
Color representation for a numeric variable
Optimize dendrogram using branch swaps and reflections.
Put close eigenvectors next to each other
Order module eigengenes by their hierarchical consensus similarity
Calculate overlap of modules
Determines significant overlap between modules in two networks based o...
Analysis of scale free topology for hard-thresholding.
Analysis of scale free topology for soft-thresholding
Annotated clustering dendrogram of microarray samples
Plot color rows in a given order, for example under a dendrogram
Red and Green Color Image of Correlation Matrix
Dendrogram plot with color annotation of objects
Eigengene network plot
Red and Green Color Image of Data Matrix
Pairwise scatterplots of eigengenes
Barplot of module significance
Plot multiple histograms in a single plot
Network heatmap plot
Estimate the population-specific mean values in an admixed population.
Parallel quantile, median, mean
Prepend a comma to a non-empty string
Pad numbers with leading zeros to specified total width
Network preservation calculations
Projective K-means (pre-)clustering of expression data
Estimate the proportion of pure populations in an admixed population b...
Proportion of variance explained by eigengenes.
Iterative pruning and merging of (hierarchical) consensus modules
Prune (hierarchical) consensus modules by removing genes with low eige...
Estimate the q-values for a given set of p-values
qvalue convenience wrapper
Rand index of two partitions
Estimate the p-value for ranking consistently high (or low) on multipl...
Repeat blockwise module detection from pre-calculated data
Repeat blockwise consensus module detection from pre-calculated data
Red-white-green color sequence
Compare prediction success
Removes the grey eigengene from a given collection of eigengenes.
Remove leading principal components from data
Replace missing values with a constant.
Return pre-defined gene lists in several biomedical categories.
Red and Green Color Specification
Blockwise module identification in sampled data
Hierarchical consensus module identification in sampled data
Calculation of fitting statistics for evaluating scale free topology f...
Visual check of scale-free topology
Select columns with the lowest consensus number of missing data
Summary correlation preservation measure
Shorten given character strings by truncating at a suitable separator.
Sigmoid-type adacency function.
Signed eigengene-based connectivity
Round numeric columns to given significant digits.
Hard-thresholding adjacency function
Simple calculation of a single consenus
Simple hierarchical consensus calculation
Simulation of expression data
Simplified simulation of expression data
Simulate eigengene network from a causal model
Simulate a gene co-expression module
Simulate multi-set expression data
Simulate small modules
Opens a graphics window with specified dimensions
Cluter merging with size restrictions
Calculates connectivity of a weighted network.
Space-less paste
Colors this library uses for labeling modules.
Standard screening for binatry traits
Standard Screening with regard to a Censored Time Variable
Standard screening for numeric traits
Standard error of the mean of a given vector.
Bar plots of data across two splitting parameters
Topological overlap for a subset of a whole set of genes
Select, swap, or reflect branches in a dendrogram.
Graphical representation of the Topological Overlap Matrix
Topological overlap matrix similarity and dissimilarity
Topological overlap matrix
Transpose a big matrix or data frame
Estimate the true trait underlying a list of surrogate markers.
Calculation of unsigned adjacency
Measure enrichment between inputted and user-defined lists
Turn a matrix into a vector of non-redundant components
Topological overlap for a subset of the whole set of genes
Barplot with error bars, annotated by Kruskal-Wallis or ANOVA p-value
Boxplot annotated by a Kruskal-Wallis p-value
Scatterplot with density
Scatterplot annotated by regression line and p-value
Voting linear predictor
Functions necessary to perform Weighted Correlation Network Analysis on high-dimensional data as originally described in Horvath and Zhang (2005) <doi:10.2202/1544-6115.1128> and Langfelder and Horvath (2008) <doi:10.1186/1471-2105-9-559>. Includes functions for rudimentary data cleaning, construction of correlation networks, module identification, summarization, and relating of variables and modules to sample traits. Also includes a number of utility functions for data manipulation and visualization.