WGCNA1.73 package

Weighted Correlation Network Analysis

accuracyMeasures

Accuracy measures for a 2x2 confusion matrix or for vectors of predict...

addErrorBars

Add error bars to a barplot.

addGrid

Add grid lines to an existing plot.

addGuideLines

Add vertical ``guide lines'' to a dendrogram plot

addTraitToMEs

Add trait information to multi-set module eigengene structure

adjacency.polyReg

Adjacency matrix based on polynomial regression

adjacency

Calculate network adjacency

adjacency.splineReg

Calculate network adjacency based on natural cubic spline regression

AFcorMI

Prediction of Weighted Mutual Information Adjacency Matrix by Correlat...

alignExpr

Align expression data with given vector

allocateJobs

Divide tasks among workers

allowWGCNAThreads

Allow and disable multi-threading for certain WGCNA calculations

automaticNetworkScreening

One-step automatic network gene screening

automaticNetworkScreeningGS

One-step automatic network gene screening with external gene significa...

BD.getData

Various basic operations on BlockwiseData objects.

bicor

Biweight Midcorrelation

bicorAndPvalue

Calculation of biweight midcorrelations and associated p-values

bicovWeights

Weights used in biweight midcovariance

binarizeCategoricalColumns

Turn categorical columns into sets of binary indicators

binarizeCategoricalVariable

Turn a categorical variable into a set of binary indicators

blockSize

Attempt to calculate an appropriate block size to maximize efficiency ...

blockwiseConsensusModules

Find consensus modules across several datasets.

blockwiseIndividualTOMs

Calculation of block-wise topological overlaps

blockwiseModules

Automatic network construction and module detection

blueWhiteRed

Blue-white-red color sequence

branchEigengeneDissim

Branch dissimilarity based on eigennodes (eigengenes).

branchSplit.dissim

Branch split based on dissimilarity.

branchSplit

Branch split.

branchSplitFromStabilityLabels

Branch split (dissimilarity) statistics derived from labels determined...

checkAdjMat

Check adjacency matrix

checkSets

Check structure and retrieve sizes of a group of datasets.

chooseOneHubInEachModule

Chooses a single hub gene in each module

chooseTopHubInEachModule

Chooses the top hub gene in each module

clusterCoef

Clustering coefficient calculation

coClustering.permutationTest

Permutation test for co-clustering

coClustering

Co-clustering measure of cluster preservation between two clusterings

collapseRows

Select one representative row per group

collapseRowsUsingKME

Selects one representative row per group based on kME

collectGarbage

Iterative garbage collection.

colQuantileC

Fast colunm- and row-wise quantile of a matrix.

conformityBasedNetworkConcepts

Calculation of conformity-based network concepts.

conformityDecomposition

Conformity and module based decomposition of a network adjacency matri...

consensusCalculation

Calculation of a (single) consenus with optional data calibration.

consensusDissTOMandTree

Consensus clustering based on topological overlap and hierarchical clu...

consensusKME

Calculate consensus kME (eigengene-based connectivities) across multip...

consensusMEDissimilarity

Consensus dissimilarity of module eigengenes.

consensusOrderMEs

Put close eigenvectors next to each other in several sets.

consensusProjectiveKMeans

Consensus projective K-means (pre-)clustering of expression data

consensusRepresentatives

Consensus selection of group representatives

consensusTOM

Consensus network (topological overlap).

consensusTreeInputs

Get all elementary inputs in a consensus tree

convertNumericColumnsToNumeric

Convert character columns that represent numbers to numeric

cor

Fast calculations of Pearson correlation.

corAndPvalue

Calculation of correlations and associated p-values

corPredictionSuccess

Qunatification of success of gene screening

corPvalueFisher

Fisher's asymptotic p-value for correlation

corPvalueStudent

Student asymptotic p-value for correlation

correlationPreservation

Preservation of eigengene correlations

coxRegressionResiduals

Deviance- and martingale residuals from a Cox regression model

cutreeStatic

Constant-height tree cut

cutreeStaticColor

Constant height tree cut using color labels

displayColors

Show colors used to label modules

dynamicMergeCut

Threshold for module merging

empiricalBayesLM

Empirical Bayes-moderated adjustment for unwanted covariates

exportNetworkToCytoscape

Export network to Cytoscape

exportNetworkToVisANT

Export network data in format readable by VisANT

factorizeNonNumericColumns

Turn non-numeric columns into factors

fixDataStructure

Put single-set data into a form useful for multiset calculations.

formatLabels

Break long character strings into multiple lines

fundamentalNetworkConcepts

Calculation of fundamental network concepts from an adjacency matrix.

GOenrichmentAnalysis

Calculation of GO enrichment (experimental)

goodGenes

Filter genes with too many missing entries

goodGenesMS

Filter genes with too many missing entries across multiple sets

goodSamples

Filter samples with too many missing entries

goodSamplesGenes

Iterative filtering of samples and genes with too many missing entries

goodSamplesGenesMS

Iterative filtering of samples and genes with too many missing entries...

goodSamplesMS

Filter samples with too many missing entries across multiple data sets

greenBlackRed

Green-black-red color sequence

greenWhiteRed

Green-white-red color sequence

GTOMdist

Generalized Topological Overlap Measure

hierarchicalConsensusCalculation

Hierarchical consensus calculation

hierarchicalConsensusKME

Calculation of measures of fuzzy module membership (KME) in hierarchic...

hierarchicalConsensusMEDissimilarity

Hierarchical consensus calculation of module eigengene dissimilarity

hierarchicalConsensusModules

Hierarchical consensus network construction and module identification

hierarchicalConsensusTOM

Calculation of hierarchical consensus topological overlap matrix

hierarchicalMergeCloseModules

Merge close (similar) hierarchical consensus modules

hubGeneSignificance

Hubgene significance

imputeByModule

Impute missing data separately in each module

individualTOMs

Calculate individual correlation network matrices

initProgInd

Inline display of progress

intramodularConnectivity

Calculation of intramodular connectivity

isMultiData

Determine whether the supplied object is a valid multiData structure

keepCommonProbes

Keep probes that are shared among given data sets

kMEcomparisonScatterplot

Function to plot kME values between two comparable data sets.

labeledBarplot

Barplot with text or color labels.

labeledHeatmap.multiPage

Labeled heatmap divided into several separate plots.

labeledHeatmap

Produce a labeled heatmap plot

labelPoints

Label scatterplot points

labels2colors

Convert numerical labels to colors.

list2multiData

Convert a list to a multiData structure and vice-versa.

lowerTri2matrix

Reconstruct a symmetric matrix from a distance (lower-triangular) repr...

matchLabels

Relabel module labels to best match the given reference labels

matrixToNetwork

Construct a network from a matrix

mergeCloseModules

Merge close modules in gene expression data

metaAnalysis

Meta-analysis of binary and continuous variables

metaZfunction

Meta-analysis Z statistic

minWhichMin

Fast joint calculation of row- or column-wise minima and indices of mi...

modifiedBisquareWeights

Modified Bisquare Weights

moduleColor.getMEprefix

Get the prefix used to label module eigengenes.

moduleEigengenes

Calculate module eigengenes.

moduleMergeUsingKME

Merge modules and reassign genes using kME.

moduleNumber

Fixed-height cut of a dendrogram.

modulePreservation

Calculation of module preservation statistics

mtd.apply

Apply a function to each set in a multiData structure.

mtd.mapply

Apply a function to elements of given multiData structures.

mtd.rbindSelf

Turn a multiData structure into a single matrix or data frame.

mtd.setAttr

Set attributes on each component of a multiData structure

mtd.setColnames

Get and set column names in a multiData structure.

mtd.simplify

If possible, simplify a multiData structure to a 3-dimensional array.

mtd.subset

Subset rows and columns in a multiData structure

multiData.eigengeneSignificance

Eigengene significance across multiple sets

multiData

Create a multiData structure.

multiGSub

Analogs of grep(l) and (g)sub for multiple patterns and relacements

multiSetMEs

Calculate module eigengenes.

multiUnion

Union and intersection of multiple sets

mutualInfoAdjacency

Calculate weighted adjacency matrices based on mutual information

nearestCentroidPredictor

Nearest centroid predictor

nearestNeighborConnectivity

Connectivity to a constant number of nearest neighbors

nearestNeighborConnectivityMS

Connectivity to a constant number of nearest neighbors across multiple...

networkConcepts

Calculations of network concepts

networkScreening

Identification of genes related to a trait

networkScreeningGS

Network gene screening with an external gene significance measure

newBlockInformation

Create a list holding information about dividing data into blocks

newBlockwiseData

Create, merge and expand BlockwiseData objects

newConsensusOptions

Create a list holding consensus calculation options.

newConsensusTree

Create a new consensus tree

newCorrelationOptions

Creates a list of correlation options.

newNetworkOptions

Create a list of network construction arguments (options).

normalizeLabels

Transform numerical labels into normal order.

nPresent

Number of present data entries.

nSets

Number of sets in a multi-set variable

numbers2colors

Color representation for a numeric variable

orderBranchesUsingHubGenes

Optimize dendrogram using branch swaps and reflections.

orderMEs

Put close eigenvectors next to each other

orderMEsByHierarchicalConsensus

Order module eigengenes by their hierarchical consensus similarity

overlapTable

Calculate overlap of modules

overlapTableUsingKME

Determines significant overlap between modules in two networks based o...

pickHardThreshold

Analysis of scale free topology for hard-thresholding.

pickSoftThreshold

Analysis of scale free topology for soft-thresholding

plotClusterTreeSamples

Annotated clustering dendrogram of microarray samples

plotColorUnderTree

Plot color rows in a given order, for example under a dendrogram

plotCor

Red and Green Color Image of Correlation Matrix

plotDendroAndColors

Dendrogram plot with color annotation of objects

plotEigengeneNetworks

Eigengene network plot

plotMat

Red and Green Color Image of Data Matrix

plotMEpairs

Pairwise scatterplots of eigengenes

plotModuleSignificance

Barplot of module significance

plotMultiHist

Plot multiple histograms in a single plot

plotNetworkHeatmap

Network heatmap plot

populationMeansInAdmixture

Estimate the population-specific mean values in an admixed population.

pquantile

Parallel quantile, median, mean

prepComma

Prepend a comma to a non-empty string

prependZeros

Pad numbers with leading zeros to specified total width

preservationNetworkConnectivity

Network preservation calculations

projectiveKMeans

Projective K-means (pre-)clustering of expression data

proportionsInAdmixture

Estimate the proportion of pure populations in an admixed population b...

propVarExplained

Proportion of variance explained by eigengenes.

pruneAndMergeConsensusModules

Iterative pruning and merging of (hierarchical) consensus modules

pruneConsensusModules

Prune (hierarchical) consensus modules by removing genes with low eige...

qvalue

Estimate the q-values for a given set of p-values

qvalue.restricted

qvalue convenience wrapper

randIndex

Rand index of two partitions

rankPvalue

Estimate the p-value for ranking consistently high (or low) on multipl...

recutBlockwiseTrees

Repeat blockwise module detection from pre-calculated data

recutConsensusTrees

Repeat blockwise consensus module detection from pre-calculated data

redWhiteGreen

Red-white-green color sequence

relativeCorPredictionSuccess

Compare prediction success

removeGreyME

Removes the grey eigengene from a given collection of eigengenes.

removePrincipalComponents

Remove leading principal components from data

replaceMissing

Replace missing values with a constant.

returnGeneSetsAsList

Return pre-defined gene lists in several biomedical categories.

rgcolors.func

Red and Green Color Specification

sampledBlockwiseModules

Blockwise module identification in sampled data

sampledHierarchicalConsensusModules

Hierarchical consensus module identification in sampled data

scaleFreeFitIndex

Calculation of fitting statistics for evaluating scale free topology f...

scaleFreePlot

Visual check of scale-free topology

selectFewestConsensusMissing

Select columns with the lowest consensus number of missing data

setCorrelationPreservation

Summary correlation preservation measure

shortenStrings

Shorten given character strings by truncating at a suitable separator.

sigmoidAdjacencyFunction

Sigmoid-type adacency function.

signedKME

Signed eigengene-based connectivity

signifNumeric

Round numeric columns to given significant digits.

signumAdjacencyFunction

Hard-thresholding adjacency function

simpleConsensusCalculation

Simple calculation of a single consenus

simpleHierarchicalConsensusCalculation

Simple hierarchical consensus calculation

simulateDatExpr

Simulation of expression data

simulateDatExpr5Modules

Simplified simulation of expression data

simulateEigengeneNetwork

Simulate eigengene network from a causal model

simulateModule

Simulate a gene co-expression module

simulateMultiExpr

Simulate multi-set expression data

simulateSmallLayer

Simulate small modules

sizeGrWindow

Opens a graphics window with specified dimensions

sizeRestrictedClusterMerge

Cluter merging with size restrictions

softConnectivity

Calculates connectivity of a weighted network.

spaste

Space-less paste

standardColors

Colors this library uses for labeling modules.

standardScreeningBinaryTrait

Standard screening for binatry traits

standardScreeningCensoredTime

Standard Screening with regard to a Censored Time Variable

standardScreeningNumericTrait

Standard screening for numeric traits

stdErr

Standard error of the mean of a given vector.

stratifiedBarplot

Bar plots of data across two splitting parameters

subsetTOM

Topological overlap for a subset of a whole set of genes

swapTwoBranches

Select, swap, or reflect branches in a dendrogram.

TOMplot

Graphical representation of the Topological Overlap Matrix

TOMsimilarity

Topological overlap matrix similarity and dissimilarity

TOMsimilarityFromExpr

Topological overlap matrix

transposeBigData

Transpose a big matrix or data frame

TrueTrait

Estimate the true trait underlying a list of surrogate markers.

unsignedAdjacency

Calculation of unsigned adjacency

userListEnrichment

Measure enrichment between inputted and user-defined lists

vectorizeMatrix

Turn a matrix into a vector of non-redundant components

vectorTOM

Topological overlap for a subset of the whole set of genes

verboseBarplot

Barplot with error bars, annotated by Kruskal-Wallis or ANOVA p-value

verboseBoxplot

Boxplot annotated by a Kruskal-Wallis p-value

verboseIplot

Scatterplot with density

verboseScatterplot

Scatterplot annotated by regression line and p-value

votingLinearPredictor

Voting linear predictor

Functions necessary to perform Weighted Correlation Network Analysis on high-dimensional data as originally described in Horvath and Zhang (2005) <doi:10.2202/1544-6115.1128> and Langfelder and Horvath (2008) <doi:10.1186/1471-2105-9-559>. Includes functions for rudimentary data cleaning, construction of correlation networks, module identification, summarization, and relating of variables and modules to sample traits. Also includes a number of utility functions for data manipulation and visualization.

  • Maintainer: Peter Langfelder
  • License: GPL (>= 2)
  • Last published: 2024-09-18