MetaIntegrator2.1.3 package

Meta-Analysis of Gene Expression Data

backwardSearch

Backward Search Function

calcMetaPower

Calculates the statistical power of a random effects meta-analysis

calculateROC

Calculate ROC Curve Statistics

calculateScore

Calculate a signature Z-score for a set of genes in a single dataset

checkDataObject

Check for errors in objects used for analysis

classFunction

Helper function to build the class vector

cleanUpPheno

Automatic preprocessing of $pheno dataframe

coconutMetaIntegrator

A wrapper function to run COCONUT on the MetaIntegrator objects.

filterGenes

Filter out significant genes from meta-analysis results

forestPlot

Compare effect sizes of a gene across all datasets in meta-analysis

forwardSearch

Forward Search Function

geneSymbolCorrection

Correct/update gene symbols in a metaObject

getGEOData

GEO download/processing through GEOquery

getMostRecentFilter

Get name of most recent filter

getSampleLevelGeneData

Extract gene-level data from a given data object

ggForestPlot

Compare effect sizes of a gene across all datasets in meta-analysis

heatmapPlot

Generates a heatmap with effect sizes for all genes which pass a filte...

immunoStatesDecov

immunoStates deconvolution analysis on MetaIntegrator object(s)

immunoStatesGenePropCorr

Correct gene expression using cell proportions from immunoStates

immunoStatesMeta

immunoStates deconvolution analysis on MetaIntegrator object(s)

imputeSex

Imputes biological sex of each sample in a Dataset object

lincsBaitCorr

Run Shane's LINCS bait-based correlation on MetaIntegrator

lincsCorrelate

Run Shane's LINCS Correlate on MetaIntegrator

lincsTools

Run Shane's LINCS Tools on MetaIntegrator

manhattanPlot

Generates a Manhattan plot with effect size FDR as y-axis

metaIntegrator_public-package

MetaIntegrator package for meta-analysis of gene expression data

multiplePRCPlot

Generate a plot with multiple PRC curves

multipleROCPlot

Generate a plot with multiple ROC curves

pooledROCPlot

Generate a plot with a pooled ROC curve

prcPlot

Plot the PRC Curve for a Dataset

predvalPlot

Plot positive and negative predictive values across different prevalen...

regressionPlot

Generate a plot which draws a regression line between the Meta Score a...

rocPlot

Plot ROC Curve for a Dataset

runMetaAnalysis

Run the meta-analysis algorithm

subsetOriginalData

Subset samples for a particular dataset

summarizeFilterResults

Summarize the filtered analysis results

summaryROCCalc

Calculate the summaryROC statistics

summaryROCPlot

Generate a plot with a summary ROC curve

violinPlot

Compare groups within a single dataset in a violin plot

A pipeline for the meta-analysis of gene expression data. We have assembled several analysis and plot functions to perform integrated multi-cohort analysis of gene expression data (meta- analysis). Methodology described in: <http://biorxiv.org/content/early/2016/08/25/071514>.