Meta-Analysis of Gene Expression Data
Backward Search Function
Calculates the statistical power of a random effects meta-analysis
Calculate ROC Curve Statistics
Calculate a signature Z-score for a set of genes in a single dataset
Check for errors in objects used for analysis
Helper function to build the class vector
Automatic preprocessing of $pheno dataframe
A wrapper function to run COCONUT on the MetaIntegrator objects.
Filter out significant genes from meta-analysis results
Compare effect sizes of a gene across all datasets in meta-analysis
Forward Search Function
Correct/update gene symbols in a metaObject
GEO download/processing through GEOquery
Get name of most recent filter
Extract gene-level data from a given data object
Compare effect sizes of a gene across all datasets in meta-analysis
Generates a heatmap with effect sizes for all genes which pass a filte...
immunoStates deconvolution analysis on MetaIntegrator object(s)
Correct gene expression using cell proportions from immunoStates
immunoStates deconvolution analysis on MetaIntegrator object(s)
Imputes biological sex of each sample in a Dataset object
Run Shane's LINCS bait-based correlation on MetaIntegrator
Run Shane's LINCS Correlate on MetaIntegrator
Run Shane's LINCS Tools on MetaIntegrator
Generates a Manhattan plot with effect size FDR as y-axis
MetaIntegrator package for meta-analysis of gene expression data
Generate a plot with multiple PRC curves
Generate a plot with multiple ROC curves
Generate a plot with a pooled ROC curve
Plot the PRC Curve for a Dataset
Plot positive and negative predictive values across different prevalen...
Generate a plot which draws a regression line between the Meta Score a...
Plot ROC Curve for a Dataset
Run the meta-analysis algorithm
Subset samples for a particular dataset
Summarize the filtered analysis results
Calculate the summaryROC statistics
Generate a plot with a summary ROC curve
Compare groups within a single dataset in a violin plot
A pipeline for the meta-analysis of gene expression data. We have assembled several analysis and plot functions to perform integrated multi-cohort analysis of gene expression data (meta- analysis). Methodology described in: <http://biorxiv.org/content/early/2016/08/25/071514>.