Clinical Trial Design, Monitoring, and Analysis - CRAN Task View

accrualPlot

Accrual Plots and Predictions for Clinical Trials

Version 1.0.7

adaptIVPT

Adaptive Bioequivalence Design for In-Vitro Permeation Tests

Version 1.1.0

adaptTest

Adaptive Two-Stage Tests

Version 1.2

adpss

Design and Analysis of Locally or Globally Efficient Adaptive Designs

Version 0.1.2

asd

Simulations for Adaptive Seamless Designs

Version 2.2

ASSISTant

Adaptive Subgroup Selection in Group Sequential Trials

Version 1.4.3

BAR

Bayesian Adaptive Randomization

Version 0.1.1

BayesCTDesign

Two Arm Bayesian Clinical Trial Design with and Without Historical Con...

Version 0.6.1

bcrm

Bayesian Continual Reassessment Method for Phase I Dose-Escalation Tri...

Version 0.5.4

BDP2

Bayesian Adaptive Designs for Phase II Trials with Binary Endpoint

Version 0.1.3

blockrand

Randomization for Block Random Clinical Trials

Version 1.5

BOIN

Bayesian Optimal INterval (BOIN) Design for Single-Agent and Drug- Com...

Version 2.7.2

brada

Bayesian Response-Adaptive Design Analysis

Version 1.0

carat

Covariate-Adaptive Randomization for Clinical Trials

Version 2.2.1

CARM

Covariate-Adjusted Adaptive Randomization via Mahalanobis-Distance

Version 1.1.0

clinfun

Clinical Trial Design and Data Analysis Functions

Version 1.1.5

clinsig

Clinical Significance Functions

Version 1.2

coin

Conditional Inference Procedures in a Permutation Test Framework

Version 1.4-3

conf.design

Construction of factorial designs

Version 2.0.0

cosa

Bound Constrained Optimal Sample Size Allocation

Version 2.1.0

covadap

Implement Covariate-Adaptive Randomization

Version 1.0.1

dfcrm

Dose-Finding by the Continual Reassessment Method

Version 0.2-2.1

ewoc

Escalation with Overdose Control

Version 0.3.0

dfmta

Phase I/II Adaptive Dose-Finding Design for MTA

Version 1.7-6

epibasix

Elementary Epidemiological Functions for Epidemiology and Biostatistic...

Version 1.5

esDesign

Adaptive Enrichment Designs with Sample Size Re-Estimation

Version 1.0.3

eselect

Adaptive Clinical Trial Designs with Endpoint Selection and Sample Siz...

Version 1.1

experiment

R Package for Designing and Analyzing Randomized Experiments

Version 1.2.1

airship

Visualization of Simulated Datasets with Multiple Simulation Input Dim...

Version 1.4.3

OncoBayes2

Bayesian Logistic Regression for Oncology Dose-Escalation Trials

Version 0.9-3

gMCP

Graph Based Multiple Comparison Procedures

Version 0.8-17

grouprar

Group Response Adaptive Randomization for Clinical Trials

Version 0.1.0

grpseq

Group Sequential Analysis of Clinical Trials

Version 1.0

gscounts

Group Sequential Designs with Negative Binomial Outcomes

Version 0.1-4

GSED

Group Sequential Enrichment Design

Version 2.6

gsrsb

Group Sequential Refined Secondary Boundary

Version 1.2.1

iAdapt

Two-Stage Adaptive Dose-Finding Clinical Trial Design

Version 2.0.1

ldbounds

Lan-DeMets Method for Group Sequential Boundaries

Version 2.0.2

longpower

Sample Size Calculations for Longitudinal Data

Version 1.0.27

MABOUST

Multi-Armed Bayesian Ordinal Utility-Based Sequential Trial

Version 1.0.1

TestDesign

Optimal Test Design Approach to Fixed and Adaptive Test Construction

Version 1.7.0

MCPMod

Design and Analysis of Dose-Finding Studies

Version 1.0-10.1

Mediana

Clinical Trial Simulations

Version 1.0.8

metaLik

Likelihood Inference in Meta-Analysis and Meta-Regression Models

Version 0.44.0

MinEDfind

A Bayesian Design for Minimum Effective Dosing-Finding Trial

Version 0.1.3

monitOS

Monitoring Overall Survival in Pivotal Trials in Indolent Cancers

Version 0.1.6

nppbib

Nonparametric Partially-Balanced Incomplete Block Design Analysis

Version 1.2-0

metasens

Statistical Methods for Sensitivity Analysis in Meta-Analysis

Version 1.5-3

rpact

Confirmatory Adaptive Clinical Trial Design and Analysis

Version 4.2.1

PK

Basic Non-Compartmental Pharmacokinetics

Version 1.3-6

pmvalsampsize

Sample Size for External Validation of a Prediction Model

Version 0.1.0

pocrm

Dose Finding in Drug Combination Phase I Trials Using PO-CRM

Version 0.13

presize

Precision Based Sample Size Calculation

Version 0.3.7

seqmon

Group Sequential Design Class for Clinical Trials

Version 2.5

rpsftm

Rank Preserving Structural Failure Time Models

Version 1.2.9

randomizeR

Randomization for Clinical Trials

Version 3.0.2

DoseFinding

Planning and Analyzing Dose Finding Experiments

Version 1.4-1

SEARS

Seamless Dose Escalation/Expansion with Adaptive Randomization Scheme

Version 0.1.0

SAME

Seamless Adaptive Multi-Arm Multi-Stage Enrichment

Version 0.1.0

remiod

Reference-Based Multiple Imputation for Ordinal/Binary Response

Version 1.0.2

UnifiedDoseFinding

Dose-Finding Methods for Non-Binary Outcomes

Version 0.1.10

RABR

Simulations for Response Adaptive Block Randomization Design

Version 0.1.1

tLagInterim

Interim Monitoring of Clinical Trials with Time-Lagged Outcome

Version 1.1

speff2trial

Semiparametric Efficient Estimation for a Two-Sample Treatment Effect

Version 1.0.5

replicateBE

Average Bioequivalence with Expanding Limits (ABEL)

Version 1.1.3

simglm

Simulate Models Based on the Generalized Linear Model

Version 0.8.9

adaptr

Adaptive Trial Simulator

Version 1.4.0

TrialSize

R Functions for Chapter 3,4,6,7,9,10,11,12,14,15 of Sample Size Calcul...

Version 1.4.1

pwr

Basic Functions for Power Analysis

Version 1.3-0

rmeta

Meta-Analysis

Version 3.0

samplesize

Sample Size Calculation for Various t-Tests and Wilcoxon-Test

Version 0.2-4

TEQR

Target Equivalence Range Design

Version 6.0-0

ThreeGroups

ML Estimator for Baseline-Placebo-Treatment (Three-Group) Experiments

Version 0.21

ssanv

Sample Size Adjusted for Nonadherence or Variability of Input Paramete...

Version 1.1

graphicalMCP

Graphical Multiple Comparison Procedures

Version 0.2.8

adaptDiag

Bayesian Adaptive Designs for Diagnostic Trials

Version 0.1.0

PowerUpR

Power Analysis Tools for Multilevel Randomized Experiments

Version 1.1.0

GroupSeq

Group Sequential Design Probabilities - With Graphical User Interface

Version 1.4.3

clinicalsignificance

A Toolbox for Clinical Significance Analyses in Intervention Studies

Version 2.1.0

logistf

Firth's Bias-Reduced Logistic Regression

Version 1.26.1

cats

Cohort Platform Trial Simulation

Version 1.0.2

CohortPlat

Simulation of Cohort Platform Trials for Combination Treatments

Version 1.0.5

PowerTOST

Power and Sample Size for (Bio)Equivalence Studies

Version 1.5-6

NCC

Simulation and Analysis of Platform Trials with Non-Concurrent Control...

Version 1.0

nlme

Linear and Nonlinear Mixed Effects Models

Version 3.1-168

metafor

Meta-Analysis Package for R

Version 4.8-0

survival

Survival Analysis

Version 3.8-3

DTAT

Dose Titration Algorithm Tuning

Version 0.3-8

gsMAMS

Group Sequential Designs of Multi-Arm Multi-Stage Trials

Version 0.7.2

RARfreq

Response Adaptive Randomization with 'Frequentist' Approaches

Version 0.1.5

SurrogateSeq

Group Sequential Testing of a Treatment Effect Using a Surrogate Marke...

Version 1.0

mice

Multivariate Imputation by Chained Equations

Version 3.18.0

crmPack

Object-Oriented Implementation of CRM Designs

Version 1.0.6

MAMS

Designing Multi-Arm Multi-Stage Studies

Version 3.0.3

escalation

A Modular Approach to Dose-Finding Clinical Trials

Version 0.1.10

nphRCT

Non-Proportional Hazards in Randomized Controlled Trials

Version 0.1.1

BinGSD

Calculate Boundaries and Conditional Power for Single Arm Group Sequen...

Version 1.1

multcomp

Simultaneous Inference in General Parametric Models

Version 1.4-28

brms.mmrm

Bayesian MMRMs using 'brms'

Version 1.1.1

gsDesign

Group Sequential Design

Version 3.7.0

adestr

Estimation in Optimal Adaptive Two-Stage Designs

Version 1.0.0

netmeta

Network Meta-Analysis using Frequentist Methods

Version 3.2-0

PwrGSD

Power in a Group Sequential Design

Version 2.3.8

lrstat

Power and Sample Size Calculation for Non-Proportional Hazards and Bey...

Version 0.2.15

BayesianMCPMod

Simulate, Evaluate, and Analyze Dose Finding Trials with Bayesian MCPM...

Version 1.2.0

mmrm

Mixed Models for Repeated Measures

Version 0.3.15

meta

General Package for Meta-Analysis

Version 8.2-1

MatchIt

Nonparametric Preprocessing for Parametric Causal Inference

Version 4.7.2

rbmi

Reference Based Multiple Imputation

Version 1.4.1

lme4

Linear Mixed-Effects Models using 'Eigen' and S4

Version 1.1-37

glmmTMB

Generalized Linear Mixed Models using Template Model Builder

Version 1.1.12

FrF2

Fractional Factorial Designs with 2-Level Factors

Version 2.3-4

HH

Statistical Analysis and Data Display: Heiberger and Holland

Version 3.1-53

ctrdata

Retrieve and Analyze Clinical Trials Data from Public Registers

Version 1.25.0